Development of an acid ceramidase activity-based probe.
نویسندگان
چکیده
Acid ceramidase is responsible for the ultimate step in the catabolism of (glyco)sphingolipids by hydrolysis of ceramide into sphingosine and free fatty acid. Deficiency in acid ceramidase is the molecular basis of Farber disease. Here we report the synthesis and characterization of an activity-based acid ceramidase probe.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 51 28 شماره
صفحات -
تاریخ انتشار 2015